exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359410 RNA Name: ADCY5 RNA Type: mRNA Chromosome: chr3 Starnd: - Coordinate: Start Site(bp): 123282296 End Site(bp): 123449758 External Links: ENSG00000173175

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPS6 chr9 19375715 19380236 - PELP1 chr17 4669774 4704337 - PHF3 chr6 63635820 63779336 + AC010422.3 chr19 12643831 12648397 - GCN1 chr12 120127202 120194715 - PINK1 chr1 20633458 20651511 + TUBB2A chr6 3153666 3157544 - HSP90AA1 chr14 102080738 102139699 - GPRC5C chr17 74424851 74451653 + RHOB chr2 20447074 20449440 + LRFN3 chr19 35935358 35946624 + AC008878.1 chr19 7507052 7519622 + DGKZ chr11 46332905 46380554 + AL136295.5 chr14 24147548 24166452 + MRPL36 chr5 1798385 1801366 - RPL3 chr22 39312882 39320389 - ICE2 chr15 60419609 60479160 - FAM83D chr20 38926312 38953106 + STK39 chr2 167954020 168247595 - THOC5 chr22 29505879 29555216 - ACOT7 chr1 6264269 6394391 - JPT2 chr16 1678256 1702280 + ZNF358 chr19 7515292 7521025 + TUBA1B chr12 49127782 49131397 - SKAP2 chr7 26667068 26995239 - RCC2 chr1 17406760 17439677 - ZNF253 chr19 19865882 19894674 + SLC37A3 chr7 140293693 140404433 - STK10 chr5 172042079 172188224 - RPL8 chr8 144789765 144792587 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092902.2 chr3 125774714 125797953 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.