exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359411 RNA Name: ADCY6 RNA Type: mRNA Chromosome: chr12 Starnd: - Coordinate: Start Site(bp): 48766194 End Site(bp): 48789037 External Links: ENSG00000174233

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MACF1 chr1 39081316 39487177 + SLC25A29 chr14 100291116 100306547 - HSP90AB1 chr6 44246166 44253888 + CALM1 chr14 90396502 90408268 + PRRT4 chr7 128350325 128361685 - LCMT1 chr16 25111731 25178231 + FLNA chrX 154348524 154374638 - TPM4 chr19 16067021 16103002 + FADS2 chr11 61792980 61867354 + MYBBP1A chr17 4538897 4555631 - UBB chr17 16380798 16382745 + RNF167 chr17 4940008 4945222 + PUS1 chr12 131929200 131945896 + LRCH4 chr7 100574011 100586129 - SELENOP chr5 42799880 42887392 - ARID1A chr1 26693236 26782104 + PEX19 chr1 160276812 160286348 - IGF2 chr11 2129112 2141238 - FNDC3B chr3 172039578 172401669 + HUWE1 chrX 53532096 53686728 - PDCD7 chr15 65117379 65133808 - LENG8 chr19 54448887 54462037 + SYNM chr15 99098217 99135593 + EME2 chr16 1772810 1781708 + FNTB chr14 64986895 65062652 + SMARCD1 chr12 50085200 50100707 + SNTB2 chr16 69187129 69309052 + ZNF628 chr19 55476617 55484487 + SNRPF chr12 95858928 95903828 + TAZ chrX 154411524 154421726 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC069281.2 chr7 100572232 100578700 - AC138761.1 chr17 22266395 22288301 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.