exRNAdisease

Entry Detail

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General Information

Database ID: exR0359425 RNA Name: ADI1 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 3497366 End Site(bp): 3519531 External Links: ENSG00000182551

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ENO3 chr17 4948092 4957131 + GNL2 chr1 37566816 37595937 - ZNF485 chr10 43606419 43617904 + CYTH2 chr19 48469208 48482314 + APP chr21 25880550 26171128 - RPL36 chr19 5674947 5691875 + SLC44A2 chr19 10602457 10644557 + PAICS chr4 56435741 56464579 + TMSB4X chrX 12975110 12977227 + RPS14 chr5 150442635 150449739 - SERPING1 chr11 57597387 57614848 + STC2 chr5 173314713 173329503 - LIMS1 chr2 108534355 108687246 + SMARCA4 chr19 10960825 11079426 + TTLL6 chr17 48762235 48817214 - MORF4L2 chrX 103675496 103688158 - ADD3 chr10 109996368 110135565 + SLC11A2 chr12 50979401 51028566 - RWDD3 chr1 95234210 95247225 + HNRNPAB chr5 178204533 178211163 + QPRT chr16 29663279 29698699 + TCF7L1 chr2 85133392 85310387 + CIZ1 chr9 128161251 128204383 - SFSWAP chr12 131711081 131799737 + MFN1 chr3 179347709 179394936 + OCIAD1 chr4 48805212 48861817 + CCT7 chr2 73233420 73253021 + VANGL2 chr1 160400564 160428670 + U2AF1L5 chr21 6484623 6499261 - SNX3 chr6 108211222 108261246 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009446.1 chr8 71675300 71702786 + AC022400.6 chr10 73703735 73713581 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.