exRNAdisease

Entry Detail

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General Information

Database ID: exR0359428 RNA Name: ADIPOR1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 202940826 End Site(bp): 202958572 External Links: ENSG00000159346

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HEATR6 chr17 60041008 60078922 - SLC25A3 chr12 98593591 98606379 + CHD8 chr14 21385194 21456126 - PMM2 chr16 8788823 8849325 + ATP6AP1 chrX 154428645 154436516 + MAP3K11 chr11 65597756 65615382 - PLSCR3 chr17 7389727 7394842 - TMED5 chr1 93149742 93180516 - HIVEP1 chr6 12008762 12164999 + HSCB chr22 28742039 28757515 + TMEM109 chr11 60914158 60923443 + PDIA4 chr7 149003062 149028662 - TUBA1B chr12 49127782 49131397 - PCNX3 chr11 65615773 65637439 + CELF1 chr11 47465933 47565569 - PLIN2 chr9 19108375 19149290 - COMMD4 chr15 75336020 75343224 + TMED3 chr15 79311112 79427432 + SC5D chr11 121292681 121313410 + TRAPPC10 chr21 44012309 44106552 + HNRNPH1 chr5 179614178 179634784 - MGAT1 chr5 180784782 180815652 - RBAK chr7 5045821 5069487 + ZC3H18 chr16 88570381 88631966 + AQR chr15 34851782 34969742 - PPIA chr7 44796680 44824564 + DOCK2 chr5 169637268 170083382 + COX7C chr5 86617928 86620962 + MARCKSL1 chr1 32333839 32336233 - NEK3 chr13 52132639 52159861 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.5 chr12 6510275 6510522 + AC010733.2 chr2 60925909 60931610 + AC022167.2 chr16 8848105 8860456 + AC020915.1 chr19 58278966 58315197 + MALAT1 chr11 65497688 65506516 + NORAD chr20 36045618 36051018 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.