exRNAdisease

Entry Detail

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General Information

Database ID: exR0359429 RNA Name: ADIPOR2 RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 1688574 End Site(bp): 1788674 External Links: ENSG00000006831

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DOCK2 chr5 169637268 170083382 + HP1BP3 chr1 20740266 20787323 - MMP15 chr16 58025754 58046901 + SKA3 chr13 21153595 21176552 - MYO5A chr15 52307283 52529050 - BRD4 chr19 15235519 15332545 - DAZAP1 chr19 1407569 1435687 + EMC6 chr17 3668812 3669668 + DBNL chr7 44044640 44069456 + CAPZA2 chr7 116811070 116922049 + VPS26C chr21 37223420 37267919 - TAGLN2 chr1 159918107 159925732 - LDHA chr11 18394560 18408425 + HADH chr4 107989714 108035175 + GALNT1 chr18 35581117 35711834 + KIF3A chr5 132692628 132737638 - HELLS chr10 94501434 94613905 + EMC10 chr19 50476400 50490870 + RPRD1A chr18 35984387 36067576 - ANKRD28 chr3 15667236 15859771 - CMTM4 chr16 66614750 66696707 - AXIN1 chr16 287440 352723 - C2orf42 chr2 70149880 70248615 - HAT1 chr2 171922448 171983686 + CDCA3 chr12 6844793 6852066 - BMP2K chr4 78776342 78916372 + ANKHD1-EIF4EBP3 chr5 140401908 140549569 + XRCC5 chr2 216107464 216206303 + SF3B1 chr2 197388515 197435091 - PUM2 chr2 20248691 20352234 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-150-5p chr19 49500832 49500853 - hsa-miR-483-3p chr11 2134142 2134162 - hsa-miR-1321 chrX 85835832 85835849 + hsa-miR-4426 chr1 192716333 192716349 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005746.1 chr17 61382785 61384680 + AL031282.2 chr1 1702736 1737688 - AL139393.2 chr6 160926269 160943110 + AP001496.2 chr18 5232876 5238526 - MALAT1 chr11 65497688 65506516 + PTPRD-AS1 chr9 8858127 8864772 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.