exRNAdisease

Entry Detail

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General Information

Database ID: exR0359453 RNA Name: ADSL RNA Type: mRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 40346500 End Site(bp): 40390463 External Links: ENSG00000239900

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MADD chr11 47269161 47330031 + HDGFL3 chr15 83112738 83207823 - CLTC chr17 59619689 59696956 + MTRNR2L10 chrX 55181392 55182442 - HNRNPR chr1 23303771 23344336 - TOMM7 chr7 22812628 22822852 - MAPK6 chr15 51952106 52067375 + STK11 chr19 1177558 1228431 + SAP30 chr4 173369969 173377532 + PPIAL4F chr1 144592868 144593652 + SND1 chr7 127652194 128092609 + PPP1R18 chr6 30676389 30687895 - BAG6 chr6 31639028 31652705 - PSMD4 chr1 151254703 151267479 + AHCY chr20 34280268 34311802 - AC104452.1 chr3 49416777 49429314 - NICN1 chr3 49422946 49429326 - ERG28 chr14 75649791 75660876 - SGSM3 chr22 40370591 40410289 + PFN2 chr3 149964904 150050788 - RPS27A chr2 55231903 55235853 + TPM3 chr1 154155304 154194648 - PHF19 chr9 120855651 120894896 - ZNF20 chr19 12092843 12140355 - PCCA chr13 100089015 100530437 + GIPC1 chr19 14477760 14496149 - EEF1A1 chr6 73515750 73523797 - DNAJA3 chr16 4425805 4456775 + EZR chr6 158765741 158819368 - SLC25A17 chr22 40769630 40819399 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-193a-5p chr17 31560016 31560037 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL031595.3 chr22 44139365 44153626 + AL050341.2 chr1 40256427 40257967 - AL139819.1 chr10 100335563 100346390 - AL353759.1 chr6 26160765 26172802 - MIR205HG chr1 209428817 209432838 + NFYC-AS1 chr1 40690380 40692066 - SNHG25 chr17 64145970 64146476 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.