exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359456 RNA Name: AEBP2 RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 19404045 End Site(bp): 19720801 External Links: ENSG00000139154

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DDX55 chr12 123602077 123620943 + NCKAP1 chr2 182909115 183038858 - AC092329.3 chr19 23222755 23274221 - FUS chr16 31180110 31194871 + HLA-F chr6 29722775 29738528 + EMD chrX 154379273 154381523 + MT-CO2 chrMT 7586 8269 + MSH5-SAPCD1 chr6 31740020 31764851 + BLOC1S2 chr10 100273280 100286680 - RAB11FIP4 chr17 31391675 31538211 + NYNRIN chr14 24399003 24419283 + ZNF724 chr19 23221599 23250390 - RPS28 chr19 8321158 8323340 + IRF2BPL chr14 77024543 77028708 - RACK1 chr5 181236897 181248096 - TTC9 chr14 70641916 70675366 + SAP18 chr13 21140514 21149084 + OCIAD1 chr4 48805212 48861817 + YBX1 chr1 42682418 42703805 + RHOBTB3 chr5 95713522 95824383 + NDUFB10 chr16 1959538 1961975 + HMGCR chr5 75336329 75362101 + NCS1 chr9 130172404 130237303 + TMEM43 chr3 14124940 14143679 + HNRNPA2B1 chr7 26173057 26201529 - COPB2 chr3 139355600 139389680 - NETO1 chr18 72742314 72868146 - RPL28 chr19 55385345 55403250 + RASGEF1C chr5 180100795 180209211 - DNAJB11 chr3 186567403 186585800 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL139260.2 chr1 38839333 38874494 - AL139819.1 chr10 100335563 100346390 - AL357078.2 chr1 65003470 65004087 - LINC01694 chr21 45593654 45603088 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.