exRNAdisease

Entry Detail

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General Information

Database ID: exR0359480 RNA Name: AGBL5 RNA Type: mRNA Chromosome: chr2 Starnd: + Coordinate: Start Site(bp): 27042364 End Site(bp): 27070622 External Links: ENSG00000084693

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CD151 chr11 832887 839831 + WDR70 chr5 37379285 37753435 + PCNA chr20 5114953 5126626 - MRPL20 chr1 1401909 1407293 - EIF4B chr12 53006158 53042209 + CBS chr21 43053191 43076943 - SMC4 chr3 160399274 160434954 + SCD chr10 100347233 100364826 + AMMECR1L chr2 127861630 127885922 - LIFR chr5 38474668 38608354 - XPO6 chr16 28097979 28211920 - HNRNPA1 chr12 54280193 54287088 + IGFBP2 chr2 216632828 216664436 + TALDO1 chr11 747415 765012 + SYVN1 chr11 65121780 65134533 - RAB8A chr19 16111889 16134234 + FNBP1 chr9 129887187 130043194 - POLR2E chr19 1086574 1095380 - SNX25 chr4 185204237 185370185 + FAM76B chr11 95768953 95790409 - RPL4 chr15 66498015 66524532 - CREBZF chr11 85659708 85682908 - SNU13 chr22 41673933 41690504 - PSMB5 chr14 23016543 23035230 - TOX4 chr14 21476597 21499175 + RPL10 chrX 154389955 154409168 + ENTPD4 chr8 23385783 23457695 - URGCP-MRPS24 chr7 43866558 43906589 - MRPS24 chr7 43866558 43869893 - TIMM50 chr19 39480412 39493785 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC002470.2 chr22 20979462 20998121 + AC026362.1 chr12 122975320 122982907 + AL139819.1 chr10 100335563 100346390 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.