exRNAdisease

Entry Detail

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General Information

Database ID: exR0359497 RNA Name: AGTPBP1 RNA Type: mRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 85546539 End Site(bp): 85742029 External Links: ENSG00000135049

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand COL5A1 chr9 134641803 134844843 + EEF2 chr19 3976056 3985463 - EPOP chr17 38671703 38674957 - CCDC88C chr14 91271323 91417844 - TADA2B chr4 7041899 7057952 + HNRNPK chr9 83968083 83980616 - RPS27A chr2 55231903 55235853 + PSMD3 chr17 39980807 39997959 + VAMP3 chr1 7771296 7781432 + GPRC5B chr16 19856691 19886167 - CCDC189 chr16 30757423 30762221 - CCAR2 chr8 22604632 22621514 + CAND2 chr3 12796472 12871916 + DNAJB6 chr7 157335381 157417439 + TPT1 chr13 45333471 45341370 - METTL7A chr12 50923472 50932510 + PLXNA3 chrX 154458281 154477779 + SMARCD1 chr12 50085200 50100707 + ST13 chr22 40824535 40856639 - U2SURP chr3 142964497 143060725 + ZNF234 chr19 44141554 44160313 + ABHD14B chr3 51968510 51983409 - TYMS chr18 657653 673578 + GATAD2B chr1 153789030 153923360 - STAT1 chr2 190908460 191020960 - RANBP1 chr22 20115938 20127355 + VTI1B chr14 67647085 67674820 - IRF4 chr6 391752 411443 + C1orf210 chr1 43281877 43285617 - CALM3 chr19 46601074 46610782 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand PDCD4-AS1 chr10 110869868 110872233 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.