exRNAdisease

Entry Detail

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General Information

Database ID: exR0359501 RNA Name: AHCTF1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 246839098 End Site(bp): 246931967 External Links: ENSG00000153207

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADGRL2 chr1 81306160 81992436 + BBX chr3 107522936 107811339 + CTNND1 chr11 57753243 57819546 + DESI2 chr1 244653103 244709033 + DIP2A chr21 46458891 46570015 + DYM chr18 49041474 49461347 - FAF1 chr1 50437028 50960267 - FAM72D chr1 145095974 145112696 + FKBP8 chr19 18531751 18544077 - GANAB chr11 62624826 62646726 - GATA4 chr8 11676959 11760002 + KLHL42 chr12 27780048 27803040 + OAZ1 chr19 2269509 2273490 + OS9 chr12 57693955 57721557 + PML chr15 73994673 74047827 + PPP2R2A chr8 26291508 26372680 + PTMA chr2 231706895 231713541 + RPL18 chr19 48615328 48619184 - RPS8 chr1 44775251 44778779 + RRM2B chr8 102204502 102238961 - RTN3 chr11 63681446 63759891 + SDHC chr1 161314257 161375340 + SRSF9 chr12 120461672 120469748 - STK35 chr20 2101827 2177038 + UBE4B chr1 10032832 10181239 + ZSWIM8 chr10 73785582 73801797 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand FTX chrX 73940435 74293574 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.