exRNAdisease

Entry Detail

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General Information

Database ID: exR0359505 RNA Name: AHDC1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 27534035 End Site(bp): 27604431 External Links: ENSG00000126705

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MTRNR2L10 chrX 55181392 55182442 - EFNB2 chr13 106489745 106535662 - DCUN1D4 chr4 51843000 51916837 + PI4KA chr22 20707691 20859417 - PABPC1 chr8 100685816 100722809 - PTBP1 chr19 797075 812327 + TMEM107 chr17 8172457 8176399 - ALDOA chr16 30064164 30070457 + ATRAID chr2 27212027 27217178 + LOXL3 chr2 74532258 74555690 - FAM32A chr19 16185380 16192046 + EDARADD chr1 236348257 236502915 + EDC4 chr16 67873052 67884499 + NUP188 chr9 128947699 129007096 + ARHGAP33 chr19 35774532 35788822 + SLC25A33 chr1 9539465 9585173 + EP400 chr12 131949942 132080460 + AIF1L chr9 131096476 131123152 + PRR14L chr22 31676256 31750140 - LPGAT1 chr1 211743457 211830763 - RPS5 chr19 58386400 58394806 + HCLS1 chr3 121631399 121660927 - TOE1 chr1 45340052 45343973 + CDK10 chr16 89680737 89696354 + ATP1A1 chr1 116372668 116410261 + NCBP1 chr9 97633668 97673748 + CRTC1 chr19 18683678 18782333 + WDR45B chr17 82614562 82648553 - GMEB2 chr20 63587602 63627101 - RMI2 chr16 11249619 11381662 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-138-5p chr16 56858527 56858549 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC138932.3 chr16 14909887 14911345 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.