exRNAdisease

Entry Detail

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General Information

Database ID: exR0359513 RNA Name: AICDA RNA Type: mRNA Chromosome: chr12 Starnd: - Coordinate: Start Site(bp): 8602170 End Site(bp): 8612867 External Links: ENSG00000111732

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ERCC5 chr13 102807146 102876001 + UBE2Z chr17 48908407 48929056 + TAPBP chr6 33299694 33314387 - ALDH9A1 chr1 165662216 165698863 - ITM2C chr2 230864639 230879248 + ACTR1B chr2 97655939 97664044 - LGMN chr14 92703807 92748679 - ABL1 chr9 130713016 130887675 + AC027644.4 chr7 66628958 66811189 + RPL30 chr8 98024851 98046469 - ATP5MG chr11 118401606 118431496 + POMT2 chr14 77274956 77320884 - RPS16 chr19 39433137 39435949 - SMUG1 chr12 54121277 54189008 - UBA2 chr19 34428352 34471251 + DCAF1 chr3 51395867 51500002 - MT-ND4 chrMT 10760 12137 + NADSYN1 chr11 71453109 71524107 + AP001781.2 chr11 111786286 111879425 - GAPDH chr12 6534512 6538374 + NACA2 chr17 61590421 61591219 - TOP2A chr17 40388525 40417896 - GAS2L3 chr12 100573683 100628288 + POLG2 chr17 64477785 64497054 - ATP5F1C chr10 7788147 7807815 + RPL8 chr8 144789765 144792587 - MTRNR2L8 chr11 10507894 10509186 - OVOL1 chr11 65787063 65797214 + RABGEF1 chr7 66682164 66811464 + SLC25A3 chr12 98593591 98606379 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-155-5p chr21 25573983 25574006 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand LINC02154 chrX 13266048 13303452 - MIR155HG chr21 25561909 25575168 + TSPOAP1-AS1 chr17 58324472 58415766 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.