exRNAdisease

Entry Detail

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General Information

Database ID: exR0359516 RNA Name: AIF1L RNA Type: mRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 131096476 End Site(bp): 131123152 External Links: ENSG00000126878

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand APEX1 chr14 20455191 20457772 + HSPD1 chr2 197486584 197516737 - SNRPG chr2 70281362 70293740 - SHC1 chr1 154962298 154974395 - AC008763.2 chr19 7629796 7643048 + PIM2 chrX 48913182 48919024 - HSP90AB1 chr6 44246166 44253888 + MT-ND2 chrMT 4470 5511 + ALDH16A1 chr19 49453225 49471050 + HK1 chr10 69269984 69401884 + RPL11 chr1 23691742 23696835 + PDS5B chr13 32586452 32778019 + MIF chr22 23894383 23895227 + XRCC5 chr2 216107464 216206303 + C17orf113 chr17 42038232 42050601 - TUBA1C chr12 49188736 49274603 + LRRC75A chr17 16441577 16492193 - OTUD1 chr10 23439458 23442390 + INTS3 chr1 153728050 153774808 + ZNF449 chrX 135344796 135363413 + FTH1 chr11 61959718 61967634 - SRPRB chr3 133784023 133825772 + MARCKSL1 chr1 32333839 32336233 - MCM3AP chr21 46235133 46286297 - PCDHGB5 chr5 141397987 141512979 + ERH chr14 69380128 69398299 - PPCDC chr15 75023586 75117462 + SMARCD1 chr12 50085200 50100707 + RPL18 chr19 48615328 48619184 - RBM14 chr11 66616582 66627347 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-641 chr19 40282603 40282626 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008267.5 chr7 66493607 66495758 + AC069503.1 chr12 122007434 122020063 - AL021707.3 chr22 38734730 38738990 + MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.