exRNAdisease

Entry Detail

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General Information

Database ID: exR0359520 RNA Name: AIG1 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 143060496 End Site(bp): 143341058 External Links: ENSG00000146416

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand NARS2 chr11 78435968 78574874 - MYO1G chr7 44962662 44979088 - ARHGAP30 chr1 161046946 161069970 - AREL1 chr14 74653437 74713108 - UBE3A chr15 25333728 25439051 - ATP2B4 chr1 203626561 203744081 + DTWD1 chr15 49621037 49656232 + RND2 chr17 43025231 43032041 + CYP26A1 chr10 93073475 93077885 + RGS12 chr4 3293028 3439913 + MT-CO2 chrMT 7586 8269 + ATRX chrX 77504878 77786233 - AC131160.1 chr3 183815568 183884889 - HSP90AB1 chr6 44246166 44253888 + DPP8 chr15 65442463 65517704 - PPP1R8 chr1 27830782 27851676 + EIF4B chr12 53006158 53042209 + FKBP1A chr20 1368978 1393172 - TUBB chr6 30720352 30725426 + HS1BP3 chr2 20560448 20651130 - ARRB2 chr17 4710596 4721499 + RNH1 chr11 494512 507300 - BOD1 chr5 173607145 173616659 - RPLP1 chr15 69452814 69456205 + GNAS chr20 58839718 58911192 + WDR12 chr2 202874782 203014798 - SLC43A3 chr11 57406954 57427580 - ST3GAL2 chr16 70375977 70439237 - TEX10 chr9 100302077 100352942 - IGFBP4 chr17 40443450 40457725 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC137630.2 chr3 48979918 48983985 - HOTAIRM1 chr7 27095647 27100265 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.