exRNAdisease

Entry Detail

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General Information

Database ID: exR0359522 RNA Name: AIMP1 RNA Type: mRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 106315544 End Site(bp): 106349456 External Links: ENSG00000164022

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TBCK chr4 106041599 106316683 - MED19 chr11 57703714 57712323 - CD2AP chr6 47477789 47627263 + DENND1C chr19 6467207 6482557 - RCOR1 chr14 102592649 102730561 + PPTC7 chr12 110533245 110583318 - ANXA5 chr4 121667946 121696995 - TRAP1 chr16 3651639 3717553 - PTOV1 chr19 49850735 49860744 + TRAPPC6B chr14 39147811 39170532 - FBXO7 chr22 32474676 32498829 + CD79A chr19 41877279 41881372 + PRRC2C chr1 171485551 171593511 + UBE3C chr7 157138916 157269370 + LRPPRC chr2 43886224 43995989 - EPCAM chr2 47345158 47387601 + RPL26 chr17 8377516 8383213 - EEF1B2 chr2 206159585 206162928 + BBS5 chr2 169479480 169506655 + RCC1 chr1 28505943 28539300 + ARID4B chr1 235131634 235328219 - PPIE chr1 39692182 39763914 + ARHGAP9 chr12 57472264 57488814 - PDPR chr16 70113626 70162537 + HLA-C chr6 31268749 31272130 - EIF4B chr12 53006158 53042209 + RPL27A chr11 8682788 8714759 + B4GALT7 chr5 177600132 177610330 + CHEK2 chr22 28687743 28742422 - RPL4 chr15 66498015 66524532 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand SNHG16 chr17 76557764 76565348 + SNHG3 chr1 28505980 28510892 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.