exRNAdisease

Entry Detail

---



General Information

Database ID: exR0359523 RNA Name: AIMP2 RNA Type: mRNA Chromosome: chr7 Starnd: + Coordinate: Start Site(bp): 6009255 End Site(bp): 6023834 External Links: ENSG00000106305

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC026954.2 chr17 7312661 7319174 - RPL36 chr19 5674947 5691875 + TFG chr3 100709331 100748964 + CCDC163 chr1 45493866 45500079 - RPL19 chr17 39200283 39204732 + PAICS chr4 56435741 56464579 + CDK16 chrX 47217860 47229997 + AC139530.2 chr17 81703371 81720539 + IMP3 chr15 75639085 75648706 - EPN1 chr19 55675226 55709858 + NDUFV1 chr11 67605653 67612554 + BFAR chr16 14632931 14669236 + PRR13 chr12 53441678 53446645 + NMT1 chr17 45051610 45109016 + EEF2 chr19 3976056 3985463 - FTSJ3 chr17 63819433 63830012 - CYP51A1 chr7 92112153 92134803 - BZW1 chr2 200810594 200827338 + MIF chr22 23894383 23895227 + MCL1 chr1 150574551 150579738 - DYNLL1 chr12 120469850 120498493 + SNX30 chr9 112750760 112881671 + SMO chr7 129188633 129213545 + GLUL chr1 182381704 182392206 - KDM4B chr19 4969113 5153598 + FBRS chr16 30658431 30670810 + RNASEK-C17orf49 chr17 7012635 7017520 + NFE2L1 chr17 48048329 48061545 + CTSB chr8 11842524 11869448 - CTNNBL1 chr20 37693955 37872129 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC245014.3 chr1 145281116 145281462 + AD000090.1 chr19 35557956 35581954 + ATP2B1-AS1 chr12 89708959 89712590 + STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + TPT1-AS1 chr13 45341345 45417975 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.