exRNAdisease

Entry Detail

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General Information

Database ID: exR0359524 RNA Name: AIP RNA Type: mRNA Chromosome: chr11 Starnd: + Coordinate: Start Site(bp): 67483026 End Site(bp): 67491103 External Links: ENSG00000110711

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand EWSR1 chr22 29268009 29300525 + EMC10 chr19 50476400 50490870 + LDHA chr11 18394560 18408425 + ANKRD13D chr11 67289300 67302485 + EIF3F chr11 7970251 8001862 + MKNK2 chr19 2037465 2051244 - MAOA chrX 43654907 43746824 + DNA2 chr10 68414064 68472121 - PKM chr15 72199029 72231822 - AP2M1 chr3 184174689 184184091 + BCL2L13 chr22 17628855 17730855 + RPS3 chr11 75399515 75422280 + BHLHE22 chr8 64580365 64583627 + TMX2 chr11 57712593 57740973 + NOL6 chr9 33461353 33473930 - APH1A chr1 150265399 150269580 - DMAC1 chr9 7796500 7888380 - GLO1 chr6 38675925 38703145 - OXLD1 chr17 81665036 81666635 - HILPDA chr7 128455849 128458418 + UIMC1 chr5 176905005 177022633 - AP002990.1 chr11 62559603 62591531 - NOP53 chr19 47745546 47757058 + GTF2A2 chr15 59638062 59657541 - NIPSNAP1 chr22 29554808 29581327 - VSTM2A chr7 54542325 54571080 + SLC25A6 chrX 1386152 1392113 - LY6E chr8 143017982 143023832 + MADD chr11 47269161 47330031 + ALCAM chr3 105366909 105576900 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005785.1 chr19 15379076 15381194 + AD000090.1 chr19 35557956 35581954 + FBXL19-AS1 chr16 30919319 30923269 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.