exRNAdisease

Entry Detail

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General Information

Database ID: exR0359528 RNA Name: AK1 RNA Type: mRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 127866486 End Site(bp): 127877675 External Links: ENSG00000106992

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABHD17C chr15 80679684 80755621 + BCL11B chr14 99169287 99272197 - C9orf16 chr9 128160265 128163924 + CBR3 chr21 36135079 36146562 + CBX5 chr12 54230942 54280133 - CLASP1 chr2 121337776 121649587 - DBNDD1 chr16 90004871 90020128 - ECI1 chr16 2239402 2252300 - EIF4A1 chr17 7572706 7579006 + HNRNPA1P48 chr16 51553436 51647132 + HNRNPA3 chr2 177212563 177223958 + IGFBP2 chr2 216632828 216664436 + KANK1 chr9 470291 746106 + LCMT1 chr16 25111731 25178231 + MANEAL chr1 37793802 37801137 + MBNL1 chr3 152243828 152465780 + NIP7 chr16 69337996 69343106 + PRCP chr11 82822936 82970584 - RPS12 chr6 132814569 132817564 + RPS19 chr19 41860255 41872925 + SAP30L chr5 154445997 154461053 + SENP3-EIF4A1 chr17 7563287 7578715 + SLC44A2 chr19 10602457 10644557 + SYNRG chr17 37514807 37609472 - TBCEL chr11 121024072 121090775 + YTHDF2 chr1 28736621 28769775 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AL157935.2 chr9 127934503 127940952 + SNHG5 chr6 85650491 85678932 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.