exRNAdisease

Entry Detail

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General Information

Database ID: exR0359551 RNA Name: AKIRIN2 RNA Type: mRNA Chromosome: chr6 Starnd: - Coordinate: Start Site(bp): 87674860 End Site(bp): 87702233 External Links: ENSG00000135334

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPS27 chr1 153990762 153992155 + PLCB3 chr11 64251523 64269150 + TM9SF4 chr20 32109714 32167258 + SLAIN2 chr4 48341529 48426201 + COX4I1 chr16 85798633 85807068 + FASN chr17 82078338 82098294 - ADGRL3 chr4 61201258 62078335 + PITX1 chr5 135027734 135034813 - RPLP0 chr12 120196699 120201235 - KLC2 chr11 66257294 66267860 + SOX4 chr6 21593751 21598619 + UBE2Z chr17 48908407 48929056 + SMARCAL1 chr2 216412414 216483053 + HCN1 chr5 45254948 45696498 - HLA-DRA chr6 32439878 32445046 + SECISBP2 chr9 89318500 89359663 + TAF7 chr5 141260225 141320784 - ELOVL5 chr6 53267398 53349179 - RPL18 chr19 48615328 48619184 - UBC chr12 124911604 124917368 - SCAND1 chr20 35953617 35959472 - TUBA1C chr12 49188736 49274603 + RACGAP1 chr12 49976923 50033136 - ACTR10 chr14 58200080 58235636 + HSP90AB1 chr6 44246166 44253888 + AFTPH chr2 64524305 64593005 + EDARADD chr1 236348257 236502915 + UBE2Q2L chr15 84172490 84182234 + MFSD11 chr17 76735865 76781449 + TP53 chr17 7661779 7687550 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-3648 chr21 8987026 8987046 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC079949.1 chr12 127142029 127146532 - AL139819.1 chr10 100335563 100346390 - RASAL2-AS1 chr1 178090677 178093984 - SNHG25 chr17 64145970 64146476 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.