exRNAdisease

Entry Detail

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General Information

Database ID: exR0359552 RNA Name: AKNA RNA Type: mRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 114334156 End Site(bp): 114394405 External Links: ENSG00000106948

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TNFAIP3 chr6 137867214 137883312 + RASGRP3 chr2 33436324 33564750 + SSR4 chrX 153793516 153798499 + RPS9 chr19 54200809 54249003 + RPS19 chr19 41860255 41872925 + ATP6V1D chr14 67294371 67360265 - UBALD2 chr17 76265348 76271298 + NDUFS4 chr5 53560633 53683338 + BRMS1 chr11 66337333 66345125 - ETFB chr19 51345169 51366418 - SKP1 chr5 134148935 134177038 - RPL11 chr1 23691742 23696835 + ABCC5 chr3 183919934 184017939 - MLST8 chr16 2204248 2209453 + RPL13 chr16 89560657 89566828 + PGRMC2 chr4 128269237 128288829 - HIKESHI chr11 86302211 86345943 + EIF4B chr12 53006158 53042209 + ERI2 chr16 20780193 20900349 - BUB3 chr10 123154402 123170467 + SHC1 chr1 154962298 154974395 - GLRX3 chr10 130136391 130184521 + HLA-DRB1 chr6 32578769 32589848 - FKBP8 chr19 18531751 18544077 - ALAS1 chr3 52198086 52214327 + TUBB chr6 30720352 30725426 + ATPAF1 chr1 46632737 46673867 - HNRNPA2B1 chr7 26173057 26201529 - PYGO2 chr1 154957026 154963853 - COX7A2L chr2 42333546 42425088 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL138895.1 chr9 114396724 114398503 - LINC00882 chr3 106449775 107240671 - MIR663AHG chr20 26167817 26251546 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.