exRNAdisease

Entry Detail

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General Information

Database ID: exR0359572 RNA Name: ALDH16A1 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 49453225 End Site(bp): 49471050 External Links: ENSG00000161618

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MED22 chr9 133338312 133348131 - SOX4 chr6 21593751 21598619 + SLC52A2 chr8 144354135 144361272 + LARGE2 chr11 45921621 45929096 + EEF1A1 chr6 73515750 73523797 - FASTK chr7 151076593 151080866 - FAT1 chr4 186587794 186726722 - LGALS9 chr17 27629798 27649560 + PPP1R10 chr6 30600413 30618612 - GRB10 chr7 50590063 50793462 - ATP6V1G2-DDX39B chr6 31530219 31546608 - SLC25A11 chr17 4937130 4940053 - GSPT1 chr16 11868128 11916082 - HOXB3 chr17 48548870 48604912 - THOP1 chr19 2785503 2815807 + CYB5B chr16 69424619 69466264 + ARFGAP1 chr20 63272785 63289790 + CBX6 chr22 38861422 38872249 - CTNNA1 chr5 138610967 138935034 + B3GALT6 chr1 1232237 1235041 + ADAMTS1 chr21 26835755 26845409 - DHX36 chr3 154272546 154324487 - ISG20L2 chr1 156721891 156728799 - CDC34 chr19 531760 542092 + ZNRF2 chr7 30284597 30367689 + BCR chr22 23179704 23318037 + EEF2 chr19 3976056 3985463 - RBM15 chr1 110338506 110346681 + GPATCH2L chr14 76151916 76254342 + DDX39B chr6 31530219 31542448 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020928.2 chr19 36773712 36775908 - AC067852.1 chr17 42536510 42562062 + AC132217.1 chr11 2129121 2129964 - VPS9D1-AS1 chr16 89711856 89718165 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.