exRNAdisease

Entry Detail

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General Information

Database ID: exR0359576 RNA Name: ALDH1B1 RNA Type: mRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 38392702 End Site(bp): 38398661 External Links: ENSG00000137124

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand UPF1 chr19 18831938 18868236 + ISG20L2 chr1 156721891 156728799 - STAU1 chr20 49113339 49188367 - SNURF chr15 24954986 24977850 + P4HB chr17 81843161 81860624 - GLYR1 chr16 4803203 4847288 - POLRMT chr19 617221 633537 - C9orf129 chr9 93318199 93346414 - LSP1 chr11 1852970 1892267 + HNRNPU chr1 244840638 244864560 - TPCN1 chr12 113221050 113298585 + LRG1 chr19 4536402 4540036 - RNF150 chr4 140859807 141212877 - CLDN6 chr16 3014712 3020071 - TXNDC5 chr6 7881517 7910788 - SSBP1 chr7 141738334 141787922 + PPP1R12A chr12 79773563 79935460 - YIPF1 chr1 53851719 53889798 - BLOC1S5-TXNDC5 chr6 7881522 8064364 - WDR70 chr5 37379285 37753435 + SPOP chr17 49598884 49678163 - TP53 chr17 7661779 7687550 - SNRPN chr15 24823637 24978723 + NOLC1 chr10 102152176 102163871 + TMEM132B chr12 125186836 125662377 + HMGA1 chr6 34236873 34246231 + LY75 chr2 159803355 159904756 - PTP4A1 chr6 63521746 63583436 + HSP90AB1 chr6 44246166 44253888 + KLC2 chr11 66257294 66267860 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020663.1 chr16 4730115 4752565 - AP003175.1 chr11 75069243 75096964 - SNHG3 chr1 28505980 28510892 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.