exRNAdisease

Entry Detail

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General Information

Database ID: exR0359579 RNA Name: ALDH2 RNA Type: mRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 111766887 End Site(bp): 111817532 External Links: ENSG00000111275

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand WASF3 chr13 26557683 26688948 + RACK1 chr5 181236897 181248096 - ANKS1A chr6 34889255 35091406 + NME2 chr17 51165435 51171747 + EIF5A chr17 7306999 7312463 + ZNF891 chr12 133106817 133130473 - NPM1 chr5 171387116 171411137 + LYSMD1 chr1 151159748 151165948 - PEX5 chr12 7188685 7218574 + RBM39 chr20 35701347 35742312 - LAMA5 chr20 62307955 62367312 - PITPNM1 chr11 67491768 67506263 - RPL28 chr19 55385345 55403250 + ANKRD11 chr16 89267630 89490561 - TUBA1C chr12 49188736 49274603 + RBPJ chr4 26163455 26435131 + PRPF19 chr11 60890547 60906585 - PRTG chr15 55611544 55743152 - ZNF671 chr19 57719751 57727624 - CSK chr15 74782057 74803198 + AC002996.1 chr12 111753890 111791418 + GPT2 chr16 46884362 46931289 + PTPN9 chr15 75463251 75579315 - SIRT7 chr17 81911939 81921323 - DR1 chr1 93345907 93369493 + ACTB chr7 5527148 5563784 - AC010422.3 chr19 12643831 12648397 - RPL13 chr16 89560657 89566828 + APOBEC3G chr22 39077067 39087743 + SIKE1 chr1 114769479 114780685 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC092117.1 chr16 2777319 2780568 + AC108134.2 chr16 3156736 3157483 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.