exRNAdisease

Entry Detail

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General Information

Database ID: exR0359584 RNA Name: ALDH6A1 RNA Type: mRNA Chromosome: chr14 Starnd: - Coordinate: Start Site(bp): 74056847 End Site(bp): 74084492 External Links: ENSG00000119711

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SYNCRIP chr6 85607785 85643792 - SRPRB chr3 133784023 133825772 + HNRNPA1L2 chr13 52642425 52643796 + SLC12A2 chr5 128083766 128189677 + KIAA0556 chr16 27550133 27780369 + RPL8 chr8 144789765 144792587 - ATP5PB chr1 111448864 111462773 + CFL1 chr11 65823022 65862026 - NOP53 chr19 47745546 47757058 + SFRP2 chr4 153780591 153789083 - METAP1 chr4 98995659 99062809 + PPP1R37 chr19 45091396 45148077 + DNAJA2 chr16 46955362 46973674 - ZNF544 chr19 58228594 58277495 + COLGALT1 chr19 17555649 17583162 + SRSF1 chr17 58000919 58007346 - BRD2 chr6 32968594 32981505 + EIF1 chr17 41688885 41692668 + BOD1 chr5 173607145 173616659 - BCL2L13 chr22 17628855 17730855 + COPS4 chr4 83034447 83075818 + TSPAN3 chr15 77041404 77083984 - CCND1 chr11 69641156 69654474 + LIN28A chr1 26410817 26429728 + PTPRU chr1 29236516 29326813 + CALM3 chr19 46601074 46610782 + AC015813.2 chr17 57989038 58007246 - RACK1 chr5 181236897 181248096 - PRPSAP2 chr17 18840085 18931287 + HSP90AB1 chr6 44246166 44253888 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand PSMA3-AS1 chr14 58265365 58298134 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.