exRNAdisease

Entry Detail

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General Information

Database ID: exR0359585 RNA Name: ALDH7A1 RNA Type: mRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 126531200 End Site(bp): 126595362 External Links: ENSG00000164904

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CNDP2 chr18 74495816 74523454 + SLC2A3 chr12 7919230 7936187 - CRISPLD1 chr8 74984505 75034558 + NUCKS1 chr1 205712822 205750182 - LIN28B chr6 104936616 105083332 + HERC2 chr15 28111040 28322172 - CALCOCO1 chr12 53708517 53727745 - DUSP16 chr12 12473282 12562863 - NASP chr1 45583846 45618904 + WDR24 chr16 684622 690444 - SBNO1 chr12 123289109 123364847 - CIB2 chr15 78104606 78131535 - EEF2 chr19 3976056 3985463 - SF3B1 chr2 197388515 197435091 - CAPZA1 chr1 112619805 112671616 + KHDRBS1 chr1 32013868 32060850 + TUBA1C chr12 49188736 49274603 + SOX13 chr1 204073115 204127743 + EIF3C chr16 28688558 28735730 + ERLIN2 chr8 37736601 37758422 + CD276 chr15 73683966 73714514 + DDHD2 chr8 38225218 38275558 + CYTL1 chr4 5014586 5019458 - WDHD1 chr14 54938949 55027105 - EIF4H chr7 74174245 74197101 + KANSL3 chr2 96593170 96642787 - SCRN1 chr7 29920104 29990289 - DPPA4 chr3 109326141 109337572 - ZNF589 chr3 48241100 48299253 + RPL23 chr17 38847860 38853764 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC012467.2 chr3 53858994 53861576 - AC016876.2 chr17 7581964 7584086 - SNHG14 chr15 24978583 25420336 + SOX21-AS1 chr13 94703454 94803430 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.