exRNAdisease

Entry Detail

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General Information

Database ID: exR0359586 RNA Name: ALDH9A1 RNA Type: mRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 165662216 End Site(bp): 165698863 External Links: ENSG00000143149

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand FYN chr6 111660332 111873452 - NIPSNAP1 chr22 29554808 29581327 - GSE1 chr16 85169525 85676204 + KCNMB4 chr12 70366290 70434292 + RPS15 chr19 1438358 1440494 + HES1 chr3 194136148 194138732 + B4GALT6 chr18 31622247 31685836 - FBRSL1 chr12 132489551 132585188 + TCF19 chr6 31158547 31167159 + RABEP2 chr16 28904421 28936526 - MORF4L2 chrX 103675496 103688158 - PCK2 chr14 24094053 24110598 + LRRFIP1 chr2 237627587 237813682 + SRSF2 chr17 76734115 76737374 - ITCH chr20 34363241 34540748 + ZNF384 chr12 6666477 6689572 - SPARC chr5 151661096 151686975 - CD55 chr1 207321376 207386804 + ENO1 chr1 8861000 8879190 - RPS6 chr9 19375715 19380236 - DDOST chr1 20651767 20661544 - SRSF3 chr6 36594353 36605600 + KHSRP chr19 6413348 6424794 - RALY chr20 33993646 34108308 + SLC4A8 chr12 51391317 51515763 + MRRF chr9 122264603 122331337 + MCM7 chr7 100092728 100101940 - DVL3 chr3 184155377 184173614 + GJA1 chr6 121435595 121449727 + MTA1 chr14 105419820 105470729 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-92a-3p chrX 134169544 134169565 - hsa-miR-1270 chr19 20399320 20399342 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC026740.1 chr5 675826 676616 + AL139819.1 chr10 100335563 100346390 - Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.