exRNAdisease

Entry Detail

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General Information

Database ID: exR0361067 RNA Name: CD74 RNA Type: mRNA Chromosome: chr5 Starnd: - Coordinate: Start Site(bp): 150400041 End Site(bp): 150412929 External Links: ENSG00000019582

Disease Information

Disease Name: Amyotrophic Lateral Sclerosis Disease Category: Nervous System Diseases MeSH ID: D000690 Type: Diseases Category/Nervous System Diseases Alias: Sclerosis, Amyotrophic Lateral//Gehrig's Disease//Gehrig Disease//Gehrigs Disease//Charcot Disease//Motor Neuron Disease, Amyotrophic Lateral Sclerosis//Lou Gehrig's Disease//Lou-Gehrigs Disease//Disease, Lou-Gehrigs//ALS - Amyotrophic Lateral Sclerosis//ALS Amyotrophic Lateral Sclerosis//Lou Gehrig Disease//Amyotrophic Lateral Sclerosis, Guam Form//Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1//Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1//Guam Form of Amyotrophic Lateral Sclerosis//Guam Disease//Disease, Guam//Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam//Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam//Amyotrophic Lateral Sclerosis With Dementia//Dementia With Amyotrophic Lateral Sclerosis

Expression Detail

GEO ID: GSE121519 Description: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid. Experimental Design: Disease vs Control Case Disease Type: Amyotrophic Lateral Sclerosis Case Disease SubType: NA Case Sample: Amyotrophic Lateral Sclerosis Control Sample: Healthy Number of Case: 4 Number of Control: 4 Number of Samples: 8

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AKT1 chr14 104769349 104795751 - A4GALT chr22 42692121 42721298 - ACTN4 chr19 38647649 38731589 + AHCY chr20 34280268 34311802 - ACTG1 chr17 81509971 81523847 - AATF chr17 36948954 37056871 + AC006064.6 chr12 6556886 6607367 - AC005258.1 chr19 2269525 2341172 + AHCYL1 chr1 109984765 110023742 + AC023055.1 chr12 55757275 55827546 - AKAP8 chr19 15353385 15379798 - ALDOA chr16 30064164 30070457 + ACTR3 chr2 113890063 113962596 + ACTR2 chr2 65227753 65271253 + AL049629.2 chr11 33698261 33722467 - ACOT9 chrX 23701055 23766475 - AK3 chr9 4709556 4742043 - ACAP1 chr17 7336529 7351477 + AC008982.1 chr19 38817471 38840178 - ADGRE1 chr19 6887566 6940459 + AL669918.1 chr6 32813767 32838822 - AC007192.1 chr19 18153158 18178117 + ACTB chr7 5527148 5563784 - AL590764.2 chrX 71103987 71111575 - AKR1B1 chr7 134442356 134459284 - ALDH18A1 chr10 95605941 95656711 - AC005670.2 chr17 46923133 47049932 + AIP chr11 67483026 67491103 + AKR7A2 chr1 19303965 19312146 - ACIN1 chr14 23058564 23095614 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-24-3p chr9 95086064 95086085 + hsa-miR-7-5p chr19 4770700 4770723 + hsa-miR-423-5p chr17 30117095 30117117 + hsa-miR-4687-3p chr11 3856113 3856133 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC007952.4 chr17 19112000 19112636 - AC016876.2 chr17 7581964 7584086 - AC020663.1 chr16 4730115 4752565 - AL137802.2 chr1 16514645 16515754 + Display:

Experiment Detail

GEO ID: GSE121519 Sample Source: Cerebrospinal Fluid Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 2 Num of detected RNAs of this Type: 17787 Sample treatment protocol: Up to 1 mL of human CSF was centrifuged at 2,000×g for 5 min and 10, 000×g for 20 min for supernatant. RNA Extract protocol: Supernatant from final centrifugation was applied to exoRNeasy spin column and RNA was extracted. RNA library preparation protocol: Whole cDNA amplification was performed with SMART-seq v4 Ultra Low Input RNA Kit. Illumina library was constructed with Nextera XT DNA Library Prep Kit.

Reference

PMID: 30630471 Title: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid Author: Otake K, Kamiguchi H, Hirozane Y Journal: BMC Med Genomics. 2019 Jan 10;12(1):7. Description: The main purpose of this study is to established the methodology of comprehensive analysis of exosomal mRNAs in CSF by a highly sensitive next-generation sequencing.