Entry Detail


General Information

Database ID:exR0409440
RNA Name:hsa-miR-143-3p
RNA Type:miRNA
Chromosome:chr5
Starnd:+
Coordinate:
Start Site(bp):149428978End Site(bp):149428998
External Links:hsa-miR-143-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACVR1B
chr12
51951699
51997078
+
BTF3L4
chr1
52056199
52090716
+
BTG2
chr1
203305491
203309602
+
CAPZB
chr1
19338775
19485539
-
CDK6
chr7
92604921
92836594
-
CELSR2
chr1
109249539
109275751
+
CIT
chr12
119685791
119877320
-
DEGS1
chr1
224175756
224193441
+
DYRK1B
chr19
39825350
39834201
-
EFNA3
chr1
155078837
155087538
+
FOSL2
chr2
28392448
28417317
+
IGFBP5
chr2
216672105
216695549
-
KRIT1
chr7
92198969
92246166
-
MAP3K3
chr17
63622415
63696303
+
NES
chr1
156668763
156677407
-
PACS1
chr11
66070272
66244744
+
PATL1
chr11
59636716
59669037
-
PNKD
chr2
218270392
218346793
+
RFWD3
chr16
74621399
74666877
-
SLC7A11
chr4
138164097
138242349
-
SON
chr21
33543038
33577481
+
STARD4
chr5
111496033
111512590
-
STMN3
chr20
63639705
63657682
-
TATDN2
chr3
10248023
10281218
+
TFPI
chr2
187464230
187565760
-
TIGD5
chr8
143597831
143603224
+
VPS37C
chr11
61130257
61161615
-
WSB1
chr17
27294076
27315926
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001247
chr22
46125304
46136418
+
hsa_circ_0000711
chr16
68155889
68160513
+
hsa_circ_0000431
chr12
102301963
102308010
+
hsa_circ_0001168
chr20
47691321
47707559
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC009022.1
chr16
69976297
70065948
-
AC091564.7
chr11
6610883
6616594
-
AC245884.8
chr19
54438665
54439544
-
DHRS4-AS1
chr14
23938219
24052555
-
LINC00667
chr18
5237826
5290608
+
LZTS1-AS1
chr8
20275773
20290458
+
MALAT1
chr11
65497688
65506516
+
MCM3AP-AS1
chr21
46229196
46259390
+
OIP5-AS1
chr15
41283990
41309737
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.