Entry Detail


General Information

Database ID:exR0409449
RNA Name:hsa-miR-148a-3p
RNA Type:miRNA
Chromosome:chr7
Starnd:-
Coordinate:
Start Site(bp):25949922End Site(bp):25949943
External Links:hsa-miR-148a-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CD151
chr11
832887
839831
+
DYRK1A
chr21
37365573
37526358
+
E2F1
chr20
33675477
33686385
-
EMP1
chr12
13196723
13219941
+
FAM47E-STBD1
chr4
76251721
76311129
+
KLF4
chr9
107484852
107490482
-
LENG8
chr19
54448887
54462037
+
LYSMD2
chr15
51723011
51751585
-
LYSMD4
chr15
99715697
99733561
-
MLPH
chr2
237485428
237555322
+
MTMR9
chr8
11284816
11328146
+
NDST1
chr5
150485818
150558211
+
NFE2L1
chr17
48048329
48061545
+
OSBPL11
chr3
125528858
125595497
-
PFAS
chr17
8247618
8270491
+
PGRMC1
chrX
119236245
119244466
+
RC3H1
chr1
173931084
174022357
-
RNF145
chr5
159157409
159210053
-
RTN4
chr2
54972187
55112621
-
SELENON
chr1
25800176
25818221
+
STARD13
chr13
33103137
33350630
-
STBD1
chr4
76306026
76311599
+
SYVN1
chr11
65121780
65134533
-
TBC1D5
chr3
17157162
18444817
-
TMF1
chr3
69019827
69052339
-
TOMM70
chr3
100363431
100401089
-
TRIM3
chr11
6448613
6474459
-
VPS45
chr1
150067279
150145329
+
ZNF512B
chr20
63956704
63969930
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0000284
chr11
33307958
33309057
+
hsa_circ_0000943
chr19
47421744
47440665
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007780.1
chr17
68413623
68524949
+
AC073896.4
chr12
56162359
56190284
-
AL049840.4
chr14
103694516
103695050
-
AL603839.3
chr1
40493157
40508661
-
H19
chr11
1995176
2001470
-
HCG18
chr6
30286690
30327382
-
KCNQ1OT1
chr11
2608328
2699994
-
LINC01089
chr12
121795267
121803906
-
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
NUTM2B-AS1
chr10
79661394
79826594
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.