Entry Detail


General Information

Database ID:exR0409478
RNA Name:hsa-miR-185-5p
RNA Type:miRNA
Chromosome:chr22
Starnd:+
Coordinate:
Start Site(bp):20033153End Site(bp):20033174
External Links:hsa-miR-185-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
TFAP2A
chr6
10393186
10419659
-
SSH2
chr17
29625938
29930276
-
ZBTB4
chr17
7459366
7484263
-
CTSA
chr20
45890144
45898820
+
TSPAN14
chr10
80454166
80533124
+
ACVR1B
chr12
51951699
51997078
+
GRB2
chr17
75318076
75405709
-
RAB5A
chr3
19947097
19985175
+
RAB40C
chr16
589357
629272
+
VPS37B
chr12
122865330
122896127
-
SLC29A1
chr6
44219553
44234142
+
NDRG1
chr8
133237171
133302022
-
HDLBP
chr2
241227264
241317061
-
RSU1
chr10
16590611
16817463
-
HADHA
chr2
26190635
26244672
-
VPS4A
chr16
69311350
69326939
+
IGF2BP1
chr17
48997385
49056145
+
NF1
chr17
31094927
31382116
+
SMAD3
chr15
67063763
67195169
+
ORAI1
chr12
121626550
121642677
+
ADGRG1
chr16
57610652
57665580
+
TNRC6B
chr22
40044817
40335808
+
ZMIZ1
chr10
79068966
79316528
+
GOLGA1
chr9
124878275
124948492
-
ZBTB38
chr3
141324213
141449792
+
SLC29A2
chr11
66362521
66372214
-
GATAD2B
chr1
153789030
153923360
-
GBA2
chr9
35736866
35749228
-
OTUD4
chr4
145110838
145180589
-
FAM234A
chr16
234521
272183
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001658
chr6
157357968
157406039
+
hsa_circ_0000711
chr16
68155889
68160513
+
hsa_circ_0001168
chr20
47691321
47707559
+
hsa_circ_0001146
chr20
34241449
34246936
-
hsa_circ_0001164
chr20
45891031
45923523
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC007952.4
chr17
19112000
19112636
-
AC008040.1
chr3
169939353
169966734
-
AC021092.1
chr19
44103007
44113183
-
LINC01278
chrX
63222993
63561095
-
MALAT1
chr11
65497688
65506516
+
MIR137HG
chr1
97933474
98049863
-
MIR663AHG
chr20
26167817
26251546
-
NEAT1
chr11
65422774
65445540
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.