Entry Detail


General Information

Database ID:exR0409497
RNA Name:hsa-miR-199b-5p
RNA Type:miRNA
Chromosome:chr9
Starnd:-
Coordinate:
Start Site(bp):128244783End Site(bp):128244805
External Links:hsa-miR-199b-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ALDH3B2
chr11
67662160
67681224
-
ATP9A
chr20
51596514
51768390
-
CHD2
chr15
92900189
93027996
+
COL4A2
chr13
110305812
110513209
+
COX6A1
chr12
120438090
120440737
+
FAM222B
chr17
28755978
28855232
-
FOSL2
chr2
28392448
28417317
+
HMGCS1
chr5
43287470
43313512
-
KRT80
chr12
52168996
52192014
-
MYRF
chr11
61752642
61788518
+
NFE2L1
chr17
48048329
48061545
+
SLC7A5
chr16
87830023
87869507
-
WNT5A
chr3
55465715
55490539
-
XPO6
chr16
28097979
28211920
-
ZMIZ1
chr10
79068966
79316528
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000591
chr15
41961025
41962156
+
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0000892
chr19
11941431
12014514
+
hsa_circ_0000931
chr19
38226804
38231095
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004951.4
chr7
43951910
44019151
-
AC095055.1
chr4
151139991
151141103
+
BX284668.2
chr1
16870945
16883659
+
LINC01783
chr1
16533886
16536172
-
POLR2J4
chr7
43940895
44019175
-
SNHG12
chr1
28578538
28583132
-
TMPO-AS1
chr12
98512973
98516422
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.