exRNAdisease

Entry Detail

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General Information

Database ID: exR0409498 RNA Name: hsa-miR-19b-3p RNA Type: miRNA Chromosome: chr13 Starnd: + Coordinate: Start Site(bp): 91351245 End Site(bp): 91351267 External Links: hsa-miR-19b-3p

Disease Information

Disease Name: Osteoarthritis Disease Category: Musculoskeletal Diseases MeSH ID: D010003 Type: Diseases Category/Musculoskeletal Diseases Alias: Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans

Expression Detail

GEO ID: GSE126677 Description: miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients Experimental Design: Disease vs Control Case Disease Type: Osteoarthritis Case Disease SubType: NA Case Sample: Osteoarthritis Control Sample: Normal Number of Case: 2 Number of Control: 3 Number of Samples: 5

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCL7A chr12 122019422 122062044 + UBA1 chrX 47190861 47215128 + RPS23 chr5 82273320 82278396 - ALDH3A2 chr17 19648136 19685760 + MEF2D chr1 156463727 156500779 - TBC1D25 chrX 48539714 48562609 + ANAPC16 chr10 72216000 72235860 + PYGB chr20 25248085 25298012 + CASP2 chr7 143288215 143307696 + TUB chr11 8019244 8106112 + SRSF6 chr20 43457893 43466046 + CAMTA1 chr1 6785454 7769706 + PMPCB chr7 103297435 103329511 + RFX1 chr19 13961530 14007039 - BTBD7 chr14 93237550 93333092 - ZNF397 chr18 35241030 35267133 + F13A1 chr6 6144084 6321013 - DNAJC16 chr1 15526813 15592379 + HOMER1 chr5 79372636 79514134 - REV1 chr2 99400475 99490035 - RAB18 chr10 27504174 27542237 + TBL1X chrX 9463295 9741037 + MTREX chr5 55307989 55425579 + PTPN21 chr14 88465778 88555007 - EIF4A2 chr3 186783205 186789897 + PATL1 chr11 59636716 59669037 - ST3GAL5 chr2 85837120 85905199 - USP14 chr18 158383 214629 + CLDN6 chr16 3014712 3020071 - COPB1 chr11 14443440 14500027 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0001186 chr21 35475133 35475818 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005394.2 chr19 28435388 28727680 - AC010997.3 chr10 75279726 75401246 - AC011498.2 chr19 4447304 4448217 + AC011503.2 chr19 23927788 23929287 + AC021078.1 chr5 149494314 149504670 - AC135050.6 chr16 31122235 31124064 + AL049840.4 chr14 103694516 103695050 - AL158206.1 chr9 19453209 19455173 + AL158825.2 chr9 75009828 75016036 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - LAMTOR5-AS1 chr1 110347116 110443817 + LINC00667 chr18 5237826 5290608 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + SNHG20 chr17 77086716 77099902 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE126677 Sample Source: Synovial Fluid Source Fraction: Extracellular Vesicle Platform: GPL16791 Method: NGS Num of detected RNA Type: 1 Num of detected RNAs of this Type: 539 Sample treatment protocol: NA RNA Extract protocol: A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids. RNA library preparation protocol: A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).

Reference

PMID: 30944259 Title: Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers. Author: Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH. Journal: JCI Insight. 2019 Apr 4;4(7). pii: 125019. Description: EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.