Entry Detail


General Information

Database ID:exR0409502
RNA Name:hsa-miR-200c-3p
RNA Type:miRNA
Chromosome:chr12
Starnd:+
Coordinate:
Start Site(bp):6963742End Site(bp):6963764
External Links:hsa-miR-200c-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CHD9
chr16
53055033
53329150
+
CTNND1
chr11
57753243
57819546
+
FOXP1
chr3
70952817
71583993
-
GPR180
chr13
94601857
94634661
+
KLF3
chr4
38664197
38701517
+
NRBP1
chr2
27427790
27442259
+
NRIP1
chr21
14961235
15065936
-
PTP4A1
chr6
63521746
63583436
+
RBM12
chr20
35648925
35664956
-
SLC35B4
chr7
134289332
134316930
-
SMAD7
chr18
48919853
48952052
-
SRP72
chr4
56467617
56503681
+
THAP2
chr12
71664301
71680644
+
XPO4
chr13
20777329
20903048
-
AC008982.1
chr19
38817471
38840178
-
CASD1
chr7
94509219
94557019
+
CEBPZ
chr2
37201612
37231596
-
ECH1
chr19
38815422
38831841
-
PSMB2
chr1
35599541
35641526
-
SNX5
chr20
17941597
17968980
-
SZRD1
chr1
16352575
16398145
+
WDR13
chrX
48590042
48608869
+
ZNF217
chr20
53567065
53609907
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001731
chr7
100731990
100738448
+
hsa_circ_0001486
chr5
56526672
56527148
+
hsa_circ_0000552
chr14
71880664
71948928
+
hsa_circ_0001358
chr3
169694733
169706147
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC024940.6
chr12
31280422
31280895
-
AC092295.2
chr19
36489649
36491040
+
AC116913.1
chr15
66488658
66492109
-
AF254983.1
chr21
10482738
10605716
+
AL049840.4
chr14
103694516
103695050
-
LINC00667
chr18
5237826
5290608
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
OIP5-AS1
chr15
41283990
41309737
+
SNHG22
chr18
49814023
49851059
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.