Entry Detail


General Information

Database ID:exR0409507
RNA Name:hsa-miR-21-5p
RNA Type:miRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):59841273End Site(bp):59841294
External Links:hsa-miR-21-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
KAZN
chr1
13892792
15118043
+
UBE2T
chr1
202331657
202341980
-
CLEC2D
chr12
9664969
9699553
+
EIF4A2
chr3
186783205
186789897
+
MGST1
chr12
16347142
16609259
+
POLE3
chr9
113407235
113410675
-
SOWAHC
chr2
109614364
109618990
+
OSER1
chr20
44195939
44210771
-
EXOC4
chr7
133253073
134066589
+
EDARADD
chr1
236348257
236502915
+
HNRNPA0
chr5
137745651
137754363
-
GPSM3
chr6
32190766
32195523
-
CTH
chr1
70411218
70439851
+
CITED2
chr6
139371807
139374648
-
MTREX
chr5
55307989
55425579
+
AP3D1
chr19
2100988
2164468
-
ELP2
chr18
36129444
36180557
+
HSPA4
chr5
133052013
133106449
+
RGS1
chr1
192575763
192580024
+
HSD17B4
chr5
119452473
119637199
+
ZFP36L1
chr14
68787660
68796253
-
HMGA1
chr6
34236873
34246231
+
EEF1B2
chr2
206159585
206162928
+
DYNC1H1
chr14
101964573
102056443
+
DUSP2
chr2
96143169
96145440
-
MCRS1
chr12
49556544
49568145
-
ATRX
chrX
77504878
77786233
-
ZADH2
chr18
75195113
75209139
-
PLIN2
chr9
19108375
19149290
-
TREX1
chr3
48465811
48467645
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001731
chr7
100731990
100738448
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC068768.1
chr12
123262060
123262402
+
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
OTUD6B-AS1
chr8
91059318
91070583
-
SNHG1
chr11
62851984
62855953
-
TUG1
chr22
30969245
30979395
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.