Entry Detail


General Information

Database ID:exR0409518
RNA Name:hsa-miR-221-3p
RNA Type:miRNA
Chromosome:chrX
Starnd:-
Coordinate:
Start Site(bp):45746180End Site(bp):45746202
External Links:hsa-miR-221-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACVR2B
chr3
38453890
38493142
+
AP3M1
chr10
74120255
74151063
-
DNAJC14
chr12
55820960
55830824
-
EFNA1
chr1
155127876
155134899
+
KDSR
chr18
63327726
63367228
-
MPZL1
chr1
167721192
167791919
+
PPIL1
chr6
36854827
36874803
-
TBL1X
chrX
9463295
9741037
+
TUB
chr11
8019244
8106112
+
ZBTB5
chr9
37438102
37465450
-
DDIT4
chr10
72273924
72276036
+
FUS
chr16
31180110
31194871
+
MAPRE1
chr20
32819954
32850405
+
RIPOR2
chr6
24804282
25042170
-
SP4
chr7
21428043
21514822
+
TUBA1B
chr12
49127782
49131397
-
ZNF649
chr19
51889235
51905040
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001247
chr22
46125304
46136418
+
hsa_circ_0000670
chr16
9199043
9199243
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC020978.7
chr16
68224713
68227734
+
AC022150.4
chr19
52650437
52653284
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
GAS5
chr1
173858559
173868882
-
NEAT1
chr11
65422774
65445540
+
TUG1
chr22
30969245
30979395
+
TYMSOS
chr18
630886
658340
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.