Entry Detail


General Information

Database ID:exR0409549
RNA Name:hsa-miR-299-3p
RNA Type:miRNA
Chromosome:chr14
Starnd:+
Coordinate:
Start Site(bp):101023832End Site(bp):101023853
External Links:hsa-miR-299-3p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AFF4
chr5
132875395
132963634
-
AK2
chr1
33007940
33080996
-
AP3M1
chr10
74120255
74151063
-
ARCN1
chr11
118572390
118603033
+
CASP2
chr7
143288215
143307696
+
CMIP
chr16
81445170
81711762
+
COL4A2
chr13
110305812
110513209
+
CORO2B
chr15
68578993
68727806
+
DHX33
chr17
5440917
5468982
-
DNAJC9
chr10
73183362
73247255
-
E2F6
chr2
11444375
11466177
-
FHL2
chr2
105357712
105438513
-
GLCCI1
chr7
7968796
8094272
+
LY6E
chr8
143017982
143023832
+
MAP3K14
chr17
45263119
45317029
-
MAP3K2
chr2
127298730
127388465
-
MAP3K20
chr2
173075435
173268015
+
MBNL1
chr3
152243828
152465780
+
MPZL1
chr1
167721192
167791919
+
PCGF3
chr4
705748
770640
+
PGK1
chrX
77910739
78129295
+
PTPRJ
chr11
47980558
48170841
+
RAB8A
chr19
16111889
16134234
+
SAMD4B
chr19
39342396
39385710
+
SORBS3
chr8
22544986
22575788
+
TCF3
chr19
1609290
1652615
-
TMEM127
chr2
96248516
96265994
-
USP37
chr2
218450251
218568351
-
ZIC1
chr3
147393422
147510293
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001349
chr3
152132729
152150709
+
hsa_circ_0001605
chr6
42903447
42905047
+
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC016876.2
chr17
7581964
7584086
-
AC135048.1
chr16
30948386
30956511
+
DSCAM-AS1
chr21
40383083
40385358
+
KCNQ1OT1
chr11
2608328
2699994
-
NEAT1
chr11
65422774
65445540
+
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.