Entry Detail


General Information

Database ID:exR0409811
RNA Name:hsa-miR-629-5p
RNA Type:miRNA
Chromosome:chr15
Starnd:-
Coordinate:
Start Site(bp):70079427End Site(bp):70079447
External Links:hsa-miR-629-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
BAZ2A
chr12
56595596
56636816
-
CBX2
chr17
79778148
79787983
+
CBX3
chr7
26201162
26213607
+
COL4A1
chr13
110148963
110307157
-
DENND5B
chr12
31382226
31591136
-
GRB10
chr7
50590063
50793462
-
HDLBP
chr2
241227264
241317061
-
LDLR
chr19
11089462
11133820
+
MCM3
chr6
52264014
52284881
-
MSI1
chr12
120341330
120369164
-
NOLC1
chr10
102152176
102163871
+
PA2G4
chr12
56104537
56113910
+
PHF12
chr17
28905250
28951771
-
PRR12
chr19
49591182
49626439
+
RSU1
chr10
16590611
16817463
-
SH3KBP1
chrX
19533977
19887600
-
SH3PXD2A
chr10
103594027
103855543
-
TULP4
chr6
158232236
158511828
+
UBN2
chr7
139230356
139308236
+
WIPF2
chr17
40219304
40284136
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000384
chr12
27867712
27877119
+
hsa_circ_0001230
chr22
38895404
38897285
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC021078.1
chr5
149494314
149504670
-
NEAT1
chr11
65422774
65445540
+
U62317.3
chr22
50597152
50597599
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.