Entry Detail


General Information

Database ID:exR0409869
RNA Name:hsa-miR-769-5p
RNA Type:miRNA
Chromosome:chr19
Starnd:+
Coordinate:
Start Site(bp):46018961End Site(bp):46018982
External Links:hsa-miR-769-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACVR1B
chr12
51951699
51997078
+
ANGEL1
chr14
76786168
76826246
-
ASB1
chr2
238426742
238452250
+
BMPR2
chr2
202376327
202567751
+
CAPNS1
chr19
36139953
36150353
+
CBFB
chr16
67028984
67101058
+
CLDN11
chr3
170418865
170454733
+
CLN8
chr8
1755778
1801711
+
DBNDD1
chr16
90004871
90020128
-
DCTN4
chr5
150708440
150759109
-
EIF1AD
chr11
65996545
66002176
-
EIF1AX
chrX
20124525
20141838
-
FOXK1
chr7
4682295
4771442
+
LONRF2
chr2
100271875
100322501
-
MDM4
chr1
204516379
204558120
+
MRTO4
chr1
19251805
19260128
+
NUSAP1
chr15
41320794
41381050
+
PLCD3
chr17
45108959
45133354
-
PRKAA1
chr5
40759379
40798374
-
PXN
chr12
120210439
120265771
-
RHPN1
chr8
143368876
143384221
+
RUNX1
chr21
34787801
36004667
-
TFAP4
chr16
4257186
4273075
-
VAT1
chr17
43014607
43025123
-
YPEL5
chr2
30146941
30160533
+
ZDHHC9
chrX
129803288
129843909
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC245033.4
chr15
82533175
82540008
-
LINC00324
chr17
8220642
8224043
-
MALAT1
chr11
65497688
65506516
+
SNHG1
chr11
62851984
62855953
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.