Entry Detail


General Information

Database ID:exR0409882
RNA Name:hsa-miR-873-5p
RNA Type:miRNA
Chromosome:chr9
Starnd:-
Coordinate:
Start Site(bp):28888925End Site(bp):28888945
External Links:hsa-miR-873-5p



Disease Information

Disease Name:Osteoarthritis
Disease Category:Musculoskeletal Diseases
MeSH ID:D010003
Type:Diseases Category/Musculoskeletal Diseases
Alias:Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans



Expression Detail

GEO ID:GSE126677
Description:miRNA sequencing of synovial fluid derived extracellular vesicles between normal and osteoarthritis (OA) patients
Experimental Design:Disease vs Control
Case Disease Type:Osteoarthritis
Case Disease SubType:NA
Case Sample:Osteoarthritis
Control Sample:Normal
Number of Case:2
Number of Control:3
Number of Samples:5





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
CACUL1
chr10
118674167
118755249
-
ICAM1
chr19
10271093
10286615
+
IDS
chrX
149476988
149521096
-
NUDT3
chr6
34279679
34392669
-
EPHA4
chr2
221418027
221574202
-
TRIOBP
chr22
37697048
37776556
+
BCL2L11
chr2
111119378
111168445
+
SEPHS2
chr16
30443631
30445874
-
PFKFB3
chr10
6144934
6254644
+
PSD3
chr8
18527303
19084730
-
PRDM15
chr21
41798225
41879482
-
DLG3
chrX
70444835
70505490
+
ORAI1
chr12
121626550
121642677
+
LMBR1
chr7
156668946
156893216
-
TRIO
chr5
14143342
14532128
+
OTUB1
chr11
63985853
64001811
+
HDGF
chr1
156742109
156766925
-
FAM222B
chr17
28755978
28855232
-
TBX3
chr12
114670255
114684175
-
BCL9L
chr11
118893875
118925608
-
CTTNBP2NL
chr1
112396214
112463456
+
CENPX
chr17
82018702
82024107
-
SMG5
chr1
156249224
156282825
-
PLAGL2
chr20
32192504
32207743
-
BICRA
chr19
47608196
47703277
+
CSNK1E
chr22
38290691
38318084
-
TMEM179B
chr11
62787402
62790400
+
DBNDD1
chr16
90004871
90020128
-
ZXDB
chrX
57591652
57597545
+
APPL2
chr12
105173297
105236203
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000417
chr12
69644908
69656342
+
hsa_circ_0000987
chr2
30748452
30756180
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC002116.1
chr19
36008638
36014235
-
AC079781.5
chr7
97851688
97972985
-
AC084809.2
chr17
32905662
32906584
+
AC239868.1
chr1
149861271
149862504
+
AC245033.4
chr15
82533175
82540008
-
AL022311.1
chr22
37876148
37895563
+
AL049543.1
chr6
28587378
28591747
+
AL355987.2
chr9
136800366
136829466
+
GAS5
chr1
173858559
173868882
-
LINC01535
chr19
37251885
37265535
+
MALAT1
chr11
65497688
65506516
+
MIR4435-2HG
chr2
111006015
111523376
-
MIR503HG
chrX
134543119
134546642
-
NEAT1
chr11
65422774
65445540
+
SNHG15
chr7
44983023
44986961
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE126677
Sample Source:Synovial Fluid
Source Fraction:Extracellular Vesicle
Platform:GPL16791
Method:NGS
Num of detected RNA Type:1
Num of detected RNAs of this Type:539
Sample treatment protocol:NA
RNA Extract protocol:A small RNA was harvested from extracellular vesicles of human synovial fluids of normal and OA patients' joints using miRCURY RNA isolation kit for biofluids.
RNA library preparation protocol:A small RNA library was generated from a customer sample using the Illumina Truseq™ Small RNA Preparation kit according to Illumina's TruSeq™ Small RNA Sample Preparation Guide (Part # 15004197).



Reference

PMID:30944259
Title:Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers.
Author:Jeon OH, Wilson DR, Clement CC, Rathod S, Cherry C, Powell B, Lee Z, Khalil AM, Green JJ, Campisi J, Santambrogio L, Witwer KW, Elisseeff JH.
Journal:JCI Insight. 2019 Apr 4;4(7). pii: 125019.
Description:EV contents found in synovial fluid may serve as a diagnostic for arthritic disease and indicator for therapeutic efficacy of senolytic treatment.