exRNAdisease

Entry Detail

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General Information

Database ID: exR0428558 RNA Name: AAAS RNA Type: mRNA Chromosome: chr12 Starnd: - Coordinate: Start Site(bp): 53307456 End Site(bp): 53324864 External Links: ENSG00000094914

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MSI1 chr12 120341330 120369164 - RPL11 chr1 23691742 23696835 + RPLP2 chr11 809965 812880 + MIF chr22 23894383 23895227 + MRPS10 chr6 42206807 42217861 - RCSD1 chr1 167630093 167708696 + LRCH4 chr7 100574011 100586129 - LRP2 chr2 169127109 169362534 - MEX3C chr18 51174550 51218304 - MTRNR2L12 chr3 96617188 96618236 - MTA1 chr14 105419820 105470729 + B2M chr15 44711487 44718877 + CDC25B chr20 3786772 3806121 + SFPQ chr1 35176378 35193145 - ZNF207 chr17 32350117 32381886 + VPS41 chr7 38722974 38932394 - RPL13 chr16 89560657 89566828 + METTL16 chr17 2405562 2511891 - MAPK14 chr6 36027677 36111236 + CD99 chrX 2691187 2741309 + YBX3 chr12 10699089 10723323 - AP000350.4 chr22 23862188 23895223 + PKM chr15 72199029 72231822 - FRAS1 chr4 78057323 78544269 + LRIG1 chr3 66378797 66501263 - RACK1 chr5 181236897 181248096 - ALDOA chr16 30064164 30070457 + MYL6 chr12 56158161 56163496 + NBR1 chr17 43170481 43211689 + LAMA5 chr20 62307955 62367312 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC069281.2 chr7 100572232 100578700 - PCAT6 chr1 202810954 202812156 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.