exRNAdisease

Entry Detail

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General Information

Database ID: exR0428563 RNA Name: AAK1 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 69457997 End Site(bp): 69674349 External Links: ENSG00000115977

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACAP2 chr3 195274745 195443044 - ADD2 chr2 70607618 70768225 - BANP chr16 87949244 88077318 + CDC42 chr1 22025511 22101360 + CDK18 chr1 205504595 205532793 + CFLAR chr2 201116154 201176687 + CHPT1 chr12 101696947 101744140 + CNDP2 chr18 74495816 74523454 + CTNNA1 chr5 138610967 138935034 + GNL3 chr3 52681156 52694497 + HCN1 chr5 45254948 45696498 - HDLBP chr2 241227264 241317061 - HUWE1 chrX 53532096 53686728 - MT-ATP6 chrMT 8527 9207 + PAICS chr4 56435741 56464579 + PPP1CB chr2 28751640 28802940 + PRRC2B chr9 131373636 131500197 + PSMB2 chr1 35599541 35641526 - PTPRZ1 chr7 121873089 122062036 + SH2B3 chr12 111405923 111451623 + SLCO3A1 chr15 91853708 92172435 + SNRNP200 chr2 96274338 96321271 - SRP14 chr15 40035690 40039181 - SSH2 chr17 29625938 29930276 - TRIM65 chr17 75880335 75896951 - TRIO chr5 14143342 14532128 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008764.6 chr19 16542746 16544814 + AC069544.1 chr10 14877688 14878686 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.