exRNAdisease

Entry Detail

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General Information

Database ID: exR0428567 RNA Name: AAR2 RNA Type: mRNA Chromosome: chr20 Starnd: + Coordinate: Start Site(bp): 36236459 End Site(bp): 36270918 External Links: ENSG00000131043

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MCM3AP chr21 46235133 46286297 - PLCB2 chr15 40278176 40307935 - MANBAL chr20 37289638 37317260 + LDHA chr11 18394560 18408425 + DHX15 chr4 24517441 24584554 - YWHAH chr22 31944522 31957603 + M6PR chr12 8940361 8949761 - LSS chr21 46188141 46228824 - MTHFR chr1 11785723 11806455 - EGLN2 chr19 40798996 40808434 + COX6B1 chr19 35648323 35658782 + PKP2 chr12 32790745 32896840 - TEN1-CDK3 chr17 75979231 76005999 + TMEM47 chrX 34627075 34657285 - HMOX2 chr16 4474690 4510347 + BRF1 chr14 105209286 105315589 - CCDC77 chr12 389273 442642 + DDX17 chr22 38483438 38507660 - NELFE chr6 31952087 31959038 - PAGR1 chr16 29816152 29822489 + LMTK2 chr7 98106862 98209638 + RAB4B-EGLN2 chr19 40778242 40808418 + HNRNPH3 chr10 68331174 68343191 + ACTR1A chr10 102461881 102502712 - CANX chr5 179678628 179731641 + MCM7 chr7 100092728 100101940 - RPL3 chr22 39312882 39320389 - FLII chr17 18244815 18258738 - TUBA1A chr12 49184795 49189080 - PAICS chr4 56435741 56464579 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-103a-3p chr5 168560904 168560926 - hsa-miR-147a chr9 120244985 120245004 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand EBLN3P chr9 37079645 37090928 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.