Entry Detail



General Information

Database ID:exR0428640
RNA Name:ABI3
RNA Type:mRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):49210411End Site(bp):49223225
External Links:ENSG00000108798



Disease Information

Disease Name:Pediatric TB meningitis
Disease Category:Infections
MeSH ID:D014390
Type:Diseases Category/Infections
Alias:Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides



Expression Detail

GEO ID:GSE122377
Description:Tuberculous Meningitis in Pediatric Patients [CSF]
Experimental Design:Disease Sample Source
Case Disease Type:Pediatric TB meningitis
Case Disease SubType:NA
Case Sample:Pediatric TB meningitis
Control Sample:Lumbar Puncture Cerebrospinal Fluid
Number of Case:12
Number of Control:12
Number of Samples:24





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010422.3
chr19
12643831
12648397
-
ANKRD46
chr8
100509752
100559784
-
CDC37
chr19
10391133
10420121
-
CFLAR
chr2
201116154
201176687
+
ETAA1
chr2
67397322
67412089
+
GRK2
chr11
67266473
67286556
+
HSPA8
chr11
123057489
123063230
-
LMNB2
chr19
2427638
2456959
-
MSN
chrX
65588377
65741931
+
MYL6B
chr12
56152256
56159647
+
PBK
chr8
27809624
27838082
-
PPP1R32
chr11
61481120
61490931
+
PPP4C
chr16
30075978
30085376
+
PTDSS2
chr11
448268
491399
+
RHOG
chr11
3826978
3840959
-
RPL8
chr8
144789765
144792587
-
RPS8
chr1
44775251
44778779
+
SKP1
chr5
134148935
134177038
-
TMEM216
chr11
61392360
61398863
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:NA
Display:



Experiment Detail

GEO ID:NA
Sample Source:NA
Source Fraction:NA
Platform:NA
Method:NA
Num of detected RNA Type:NA
Num of detected RNAs of this Type:NA
Sample treatment protocol:NA
RNA Extract protocol:NA
RNA library preparation protocol:NA



Reference

PMID:31434901
Title:Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
Author:Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ
Journal:Nat Commun. 2019 Aug 21;10(1):3767.
Description:Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.