exRNAdisease

Entry Detail

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General Information

Database ID: exR0428654 RNA Name: ABT1 RNA Type: mRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 26596953 End Site(bp): 26600739 External Links: ENSG00000146109

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HSP90AB1 chr6 44246166 44253888 + RPS20 chr8 56067295 56074581 - SLC37A4 chr11 119024114 119030906 - PAFAH1B2 chr11 117144284 117176894 + RNASEH2C chr11 65714005 65720818 - CLTA chr9 36190856 36304781 + USF1 chr1 161039251 161045977 - POR chr7 75899200 75986855 + ENO1 chr1 8861000 8879190 - RPL22L1 chr3 170864875 170870208 - RAN chr12 130872037 130877678 + GSTP1 chr11 67583742 67586656 + PDLIM1 chr10 95237572 95291012 - MPDU1 chr17 7583529 7592789 + HSPD1 chr2 197486584 197516737 - THOC5 chr22 29505879 29555216 - PAK1IP1 chr6 10694972 10709782 + CHCHD10 chr22 23765834 23768443 - DHRS4L2 chr14 23969874 24006408 + GFOD1 chr6 13357830 13487662 - DNAJC14 chr12 55820960 55830824 - NFE2L1 chr17 48048329 48061545 + SFRP1 chr8 41261962 41309473 - B2M chr15 44711487 44718877 + BABAM1 chr19 17267376 17281249 + GTPBP1 chr22 38705742 38738299 + IL4R chr16 27313668 27364778 + HLA-DRA chr6 32439878 32445046 + MCFD2 chr2 46901870 46941855 - EEF1A1 chr6 73515750 73523797 - miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-873-5p chr9 28888925 28888945 - circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008969.1 chr19 58002061 58011232 + AC020663.1 chr16 4730115 4752565 - MALAT1 chr11 65497688 65506516 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.