exRNAdisease

Entry Detail

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General Information

Database ID: exR0428681 RNA Name: AC011462.1 RNA Type: mRNA Chromosome: chr19 Starnd: + Coordinate: Start Site(bp): 41350853 End Site(bp): 41425001 External Links: ENSG00000255730

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010422.3 chr19 12643831 12648397 - ADD3 chr10 109996368 110135565 + RPS18 chr6 33272075 33276511 + HMG20B chr19 3572777 3579088 + PARP1 chr1 226360691 226408093 - EIF4B chr12 53006158 53042209 + RPS17 chr15 82536750 82540459 - NUP62 chr19 49906825 49929763 - PPIA chr7 44796680 44824564 + AC011448.1 chr19 19516227 19536076 + EIF3D chr22 36510855 36529184 - ATP5ME chr4 672436 674330 - MCL1 chr1 150574551 150579738 - PRRC2A chr6 31620715 31637771 + LSM4 chr19 18306230 18323274 - TAGLN2 chr1 159918107 159925732 - RING1 chr6 33208500 33212722 + SND1 chr7 127652194 128092609 + CYB561A3 chr11 61348745 61362299 - RNASEH2C chr11 65714005 65720818 - TRAF4 chr17 28744005 28750956 + HLA-B chr6 31269491 31357188 - SALL2 chr14 21521080 21537216 - IPO13 chr1 43946950 43968022 + RPS15 chr19 1438358 1440494 + Z83844.3 chr22 37639693 37666932 + PTP4A3 chr8 141391995 141432454 + DESI1 chr22 41598028 41621043 - ICAM1 chr19 10271093 10286615 + B2M chr15 44711487 44718877 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand RMRP chr9 35657751 35658018 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.