exRNAdisease

Entry Detail

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General Information

Database ID: exR0428702 RNA Name: AC068547.1 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 151802651 End Site(bp): 151973949 External Links: ENSG00000283228

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SEPHS1 chr10 13317428 13348298 - BIRC2 chr11 102347211 102378670 + ELF3 chr1 202007945 202017183 + DAP3 chr1 155687960 155739010 + ACTN1 chr14 68874143 68979440 - PDCD6IP chr3 33798571 33869707 + DDIT4 chr10 72273924 72276036 + PAX7 chr1 18630846 18748866 + NCOA4 chr10 46005088 46030714 - PCSK1N chrX 48831096 48835610 - CBX3 chr7 26201162 26213607 + RPS5 chr19 58386400 58394806 + STK32C chr10 132207492 132331847 - INS-IGF2 chr11 2132538 2161209 - CTSB chr8 11842524 11869448 - ZFP36L2 chr2 43222402 43226606 - CACNB4 chr2 151832768 152099475 - ARL5A chr2 151788984 151828492 - TPP2 chr13 102596986 102679958 + CACNB1 chr17 39173453 39197703 - PSMD13 chr11 236966 252984 + SRSF2 chr17 76734115 76737374 - IGF2 chr11 2129112 2141238 - RIOK2 chr5 97160867 97183247 - CCL5 chr17 35871491 35880793 - PTMA chr2 231706895 231713541 + EIF1AX chrX 20124525 20141838 - ZNF92 chr7 65373799 65401135 + RPL37A chr2 216498825 216579180 + RPS6KB1 chr17 59893046 59950574 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL591742.2 chr1 114032393 114034511 + LINC01551 chr14 28771676 28823817 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.