exRNAdisease

Entry Detail

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General Information

Database ID: exR0428706 RNA Name: AC068946.1 RNA Type: mRNA Chromosome: chr2 Starnd: - Coordinate: Start Site(bp): 219075329 End Site(bp): 219170827 External Links: ENSG00000280537

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand SIM2 chr21 36699115 36749917 + APEX1 chr14 20455191 20457772 + ANAPC5 chr12 121308245 121399896 - PES1 chr22 30576625 30607083 - HGH1 chr8 144137774 144140851 + PTMA chr2 231706895 231713541 + RPL13A chr19 49487554 49492308 + CFAP43 chr10 104129888 104232364 - XRCC6 chr22 41621119 41664048 + EMC9 chr14 24138959 24141591 - MSH2 chr2 47403067 47663146 + LSG1 chr3 194640791 194672463 - APPL2 chr12 105173297 105236203 - BHLHE40 chr3 4979437 4985323 + EDARADD chr1 236348257 236502915 + SLC23A3 chr2 219161465 219170095 - HSP90AB1 chr6 44246166 44253888 + PPIA chr7 44796680 44824564 + TWF1 chr12 43793723 43806375 - HSPA1B chr6 31827738 31830254 + HNRNPH1 chr5 179614178 179634784 - RFLNA chr12 123973241 124316024 + GAPDH chr12 6534512 6538374 + LFNG chr7 2512529 2529177 + ATG9A chr2 219219380 219229717 - PPM1A chr14 60245752 60299087 + NHEJ1 chr2 219075317 219160865 - SPINT2 chr19 38244035 38292615 + RPS27A chr2 55231903 55235853 + OAZ2 chr15 64687573 64703281 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011461.1 chr19 10490339 10491000 - AL355075.4 chr14 20343048 20343685 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.