exRNAdisease

Entry Detail

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General Information

Database ID: exR0428718 RNA Name: AC093323.1 RNA Type: mRNA Chromosome: chr4 Starnd: + Coordinate: Start Site(bp): 6663396 End Site(bp): 6676755 External Links: ENSG00000170846

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DSE chr6 116254173 116444861 + DNAJC4 chr11 64230278 64234286 + KRT8 chr12 52897187 52949954 - GRSF1 chr4 70815783 70839897 - FUBP3 chr9 130578965 130638352 + COX8A chr11 63974620 63976543 + CLDN6 chr16 3014712 3020071 - PRKAR1A chr17 68511780 68551319 + GPR135 chr14 59429022 59465342 - P2RX5-TAX1BP3 chr17 3663063 3696194 - AP1M1 chr19 16197578 16245907 + PTMA chr2 231706895 231713541 + LASP1 chr17 38869859 38921770 + CRTAP chr3 33114014 33147773 + DDX24 chr14 94048287 94081212 - SMC4 chr3 160399274 160434954 + PKM chr15 72199029 72231822 - UGP2 chr2 63840940 63891562 + WBP1 chr2 74458400 74460891 + TAX1BP3 chr17 3662895 3668679 - RAB4A chr1 229271062 229305894 + NDUFA1 chrX 119871832 119876662 + IGFBP3 chr7 45912245 45921874 - ASPSCR1 chr17 81976807 82017406 + ANKRD40 chr17 50693198 50707914 - COPB1 chr11 14443440 14500027 - GDE1 chr16 19501693 19522123 - RTL8C chrX 135032355 135033546 + PHC1 chr12 8913896 8941467 + TKT chr3 53224712 53256052 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.