exRNAdisease

Entry Detail

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General Information

Database ID: exR0428728 RNA Name: AC118553.2 RNA Type: mRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 99970011 End Site(bp): 100083321 External Links: ENSG00000283761

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CFL1 chr11 65823022 65862026 - BAK1 chr6 33572547 33580293 - SLC35A3 chr1 99969351 100035634 + TMEM69 chr1 45688181 45694436 + MBNL1 chr3 152243828 152465780 + VDAC2 chr10 75210154 75231448 + SRP72 chr4 56467617 56503681 + YEATS2 chr3 183697797 183812624 + ADD1 chr4 2843857 2930076 + PFDN5 chr12 53295291 53299450 + UGP2 chr2 63840940 63891562 + MRFAP1 chr4 6640091 6642745 + GOT2 chr16 58707131 58734342 - USP34 chr2 61187463 61471087 - TJP2 chr9 69121264 69274615 + SPRYD7 chr13 49912702 49936490 - CKS2 chr9 89311195 89316703 + EEF1G chr11 62559596 62574086 - COPE chr19 18899514 18919387 - HIF1AN chr10 100529072 100559998 + IGFBP2 chr2 216632828 216664436 + PODXL chr7 131500262 131558217 - RALBP1 chr18 9475009 9538114 + SNAP23 chr15 42491233 42545356 + BAZ1B chr7 73440406 73522293 - FADS1 chr11 61799627 61829318 - TMEM256 chr17 7402975 7404097 - SLC12A8 chr3 125082636 125212864 - MFSD14A chr1 100038095 100083377 + IMP3 chr15 75639085 75648706 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AP001496.2 chr18 5232876 5238526 - EPB41L4A-AS1 chr5 112160526 112164818 + SNHG12 chr1 28578538 28583132 - Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.