exRNAdisease

Entry Detail

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General Information

Database ID: exR0428740 RNA Name: ACAA2 RNA Type: mRNA Chromosome: chr18 Starnd: - Coordinate: Start Site(bp): 49782164 End Site(bp): 49813953 External Links: ENSG00000167315

Disease Information

Disease Name: Pediatric TB meningitis Disease Category: Infections MeSH ID: D014390 Type: Diseases Category/Infections Alias: Tuberculosis, Meningeal//Meningeal Tuberculoses//Meningeal Tuberculosis//Tuberculoses, Meningeal//TB Meningitis//TB Meningitides//Tubercular Meningitis//Meningitides, Tubercular//Meningitis, Tubercular//Tubercular Meningitides//Meningitis, Tuberculous//Meningitides, Tuberculous//Tuberculous Meningitides//Tuberculous Meningitis//Tuberculosis Meningitis//Meningitides, Tuberculosis//Meningitis, Tuberculosis//Tuberculosis Meningitides//Tuberculous Hypertrophic Pachymeningitis//Hypertrophic Pachymeningitides, Tuberculous//Hypertrophic Pachymeningitis, Tuberculous//Pachymeningitides, Tuberculous Hypertrophic//Pachymeningitis, Tuberculous Hypertrophic//Tuberculous Hypertrophic Pachymeningitides

Expression Detail

GEO ID: GSE122377 Description: Tuberculous Meningitis in Pediatric Patients [CSF] Experimental Design: Disease Sample Source Case Disease Type: Pediatric TB meningitis Case Disease SubType: NA Case Sample: Pediatric TB meningitis Control Sample: Lumbar Puncture Cerebrospinal Fluid Number of Case: 12 Number of Control: 12 Number of Samples: 24

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand DCAF5 chr14 69050881 69153150 - PSMA6 chr14 35278633 35317493 + RPL13 chr16 89560657 89566828 + GSPT1 chr16 11868128 11916082 - GABARAP chr17 7240008 7242449 - DNAJC1 chr10 21756548 22003769 - LRRN1 chr3 3799431 3849834 + SRSF7 chr2 38743599 38751494 - MAPKAP1 chr9 125437393 125707234 - CLDND1 chr3 98497912 98523066 - AC120057.2 chr17 7240427 7244635 - KDM5C chrX 53191321 53225422 - RAB6A chr11 73675638 73761137 - EXOC6B chr2 72175984 72826041 - CDC20 chr1 43358981 43363203 + SF3B6 chr2 24067586 24076373 - UBL5 chr19 9827892 9830115 + MTRNR2L12 chr3 96617188 96618236 - HACD4 chr9 20999509 21031640 - RAN chr12 130872037 130877678 + RAD17 chr5 69369293 69414801 + RPS6 chr9 19375715 19380236 - REEP5 chr5 112876385 112922289 - LRRFIP1 chr2 237627587 237813682 + VASP chr19 45506579 45526983 + CAPN1 chr11 65180566 65212006 + CKAP5 chr11 46743048 46846308 - NTS chr12 85874295 85882992 + ERN1 chr17 64039142 64130819 - PRDX6 chr1 173477330 173488815 + miRNA targets: miRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa-miR-492 chr12 94834427 94834449 + circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC026362.1 chr12 122975320 122982907 + AD000090.1 chr19 35557956 35581954 + Display:

Experiment Detail

GEO ID: NA Sample Source: NA Source Fraction: NA Platform: NA Method: NA Num of detected RNA Type: NA Num of detected RNAs of this Type: NA Sample treatment protocol: NA RNA Extract protocol: NA RNA library preparation protocol: NA

Reference

PMID: 31434901 Title: Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity Author: Rohlwink UK, Figaji A, Wilkinson KA, Horswell S, Sesay AK, Deffur A, Enslin N, Solomons R, Van Toorn R, Eley B, Levin M, Wilkinson RJ, Lai RPJ Journal: Nat Commun. 2019 Aug 21;10(1):3767. Description: Differential transcript expression of TBM cases are compared with healthy controls in whole blood and with non-TB cerebral infection controls in CSF.